CATH Classification

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Histone acetyltransferase KAT2B

Enzyme Information

2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt Q92831
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.
2.3.1.57
Diamine N-acetyltransferase.
based on mapping to UniProt Q92831
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
-!- Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)- acetylspermidine and N(8)-acetylspermidine.

UniProtKB Entries (1)

Q92831
KAT2B_HUMAN
Homo sapiens
Histone acetyltransferase KAT2B

PDB Structure

PDB 5FE0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.
Chaikuad, A., Lang, S., Brennan, P.E., Temperini, C., Fedorov, O., Hollander, J., Nachane, R., Abell, C., Muller, S., Siegal, G., Knapp, S.
J.Med.Chem.