CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.200 | Fumarase C; Chain A, domain 2 |
|
1.20.200.10 | Fumarase/aspartase (Central domain) |
Domain Context
CATH Clusters
| Superfamily | Fumarase/aspartase (Central domain) |
| Functional Family | Fumarate hydratase, mitochondrial |
Enzyme Information
| 4.2.1.2 |
Fumarate hydratase.
based on mapping to UniProt P9WN92
(S)-malate = fumarate + H(2)O.
|
UniProtKB Entries (1)
| P9WN92 |
FUMC_MYCTO
Mycobacterium tuberculosis CDC1551
Fumarate hydratase class II
|
PDB Structure
| PDB | 5F91 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Proc.Natl.Acad.Sci.USA
|