CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Serine/threonine-protein kinase Chk1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14757
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14757
CHK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase Chk1

PDB Structure

PDB 5F4N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
Osborne, J.D., Matthews, T.P., McHardy, T., Proisy, N., Cheung, K.M., Lainchbury, M., Brown, N., Walton, M.I., Eve, P.D., Boxall, K.J., Hayes, A., Henley, A.T., Valenti, M.R., De Haven Brandon, A.K., Box, G., Jamin, Y., Robinson, S.P., Westwood, I.M., van Montfort, R.L., Leonard, P.M., Lamers, M.B., Reader, J.C., Aherne, G.W., Raynaud, F.I., Eccles, S.A., Garrett, M.D., Collins, I.
J.Med.Chem.