CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P29597
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29597
TYK2_HUMAN
Homo sapiens
Non-receptor tyrosine-protein kinase TYK2

PDB Structure

PDB 5F20
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors.
Yogo, T., Nagamiya, H., Seto, M., Sasaki, S., Shih-Chung, H., Ohba, Y., Tokunaga, N., Lee, G.N., Rhim, C.Y., Yoon, C.H., Cho, S.Y., Skene, R., Yamamoto, S., Satou, Y., Kuno, M., Miyazaki, T., Nakagawa, H., Okabe, A., Marui, S., Aso, K., Yoshida, M.
J.Med.Chem.