CATH Domain 5ez1A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P56112

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P56112

Y175_HELPY

Helicobacter pylori 26695

Putative peptidyl-prolyl cis-trans isomerase HP_0175

PDB Structure

PDB	5EZ1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Helicobacter pylori cell binding factor 2: Insights into domain motion. Naveen, V., Chu, C.H., Chen, B.W., Tsai, Y.C., Hsiao, C.D., Sun, Y.J. J.Struct.Biol.