CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.30.30
Functional Family heat shock 70 kDa protein-like

Enzyme Information

3.6.4.10
Non-chaperonin molecular chaperone ATPase.
based on mapping to UniProt P11021
ATP + H(2)O = ADP + phosphate.
-!- This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. -!- They comprise a number of heat-shock-cognate proteins. -!- They are also active in clathrin uncoating and in the oligomerization of actin.

UniProtKB Entries (1)

P11021
BIP_HUMAN
Homo sapiens
Endoplasmic reticulum chaperone BiP

PDB Structure

PDB 5EY4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.
Hughes, S.J., Antoshchenko, T., Chen, Y., Lu, H., Pizarro, J.C., Park, H.W.
Plos One