CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.1.-.-
Acting on ester bonds.
based on mapping to UniProt Q98VG9
3.6.4.13
RNA helicase.
based on mapping to UniProt Q98VG9
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt Q98VG9
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.4.22.-
Cysteine endopeptidases.
based on mapping to UniProt Q98VG9
2.1.1.-
Methyltransferases.
based on mapping to UniProt Q98VG9
3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q98VG9
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.
3.1.13.-
Exoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt Q98VG9
3.6.4.12
DNA helicase.
based on mapping to UniProt Q98VG9
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q98VG9
R1AB_FIPV
Feline infectious peritonitis virus (strain 79-1146)
Replicase polyprotein 1ab

PDB Structure

PDB 5EU8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors
Wang, F., Chen, C., Liu, X., Yang, K., Xu, X., Yang, H.
J.Virol.