CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P04642
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P04642
LDHA_RAT
Rattus norvegicus
L-lactate dehydrogenase A chain

PDB Structure

PDB 5ES3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using AKTAxpressTM.
Nowicki, M.W., Blackburn, E.A., McNae, I.W., Wear, M.A.
Plos One