CATH Classification

Domain Context

CATH Clusters

Superfamily Molybdopterin biosynthesis moea protein, domain 3.
Functional Family

Enzyme Information

2.7.7.75
Molybdopterin adenylyltransferase.
based on mapping to UniProt Q03555
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
-!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). -!- The reaction requires a divalent cation such as Mg(2+) or Mn(2+). -!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes EC 2.10.1.1. -!- Formerly EC 2.7.7.n5.
2.10.1.1
Molybdopterin molybdotransferase.
based on mapping to UniProt Q03555
Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.
-!- Catalyzes the insertion of molybdenum into the ene-dithiol group of molybdopterin. -!- In eukaryotes this reaction is catalyzed by the N-terminal domain of a fusion protein whose C-terminal domain catalyzes EC 2.7.7.75.

UniProtKB Entries (1)

Q03555
GEPH_RAT
Rattus norvegicus
Gephyrin

PDB Structure

PDB 5ERQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.
Kasaragod, V.B., Schindelin, H.
Structure