CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 |
Enzyme Information
| 2.1.1.220 |
tRNA (adenine(58)-N(1))-methyltransferase.
based on mapping to UniProt P46959
S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
-!- The enzyme specifically methylates adenine(58) in tRNA. -!- The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast. -!- Formerly EC 2.1.1.36.
|
UniProtKB Entries (1)
| P46959 |
TRM61_YEAST
Saccharomyces cerevisiae S288C
TRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61
|
PDB Structure
| PDB | 5ERG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
Sci Rep
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