CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family Zinc-containing alcohol dehydrogenase superfamily

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P00330
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P00330
ADH1_YEAST
Saccharomyces cerevisiae S288C
Alcohol dehydrogenase 1

PDB Structure

PDB 5ENV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol.
Plapp, B.V., Charlier, H.A., Ramaswamy, S.
Arch.Biochem.Biophys.