CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein phosphatase non-receptor type

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q06124
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

Q06124
PTN11_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 11

PDB Structure

PDB 5EHR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Chen, Y.P., LaMarche, M.J., Chan, H.M., Fekkes, P., Garcia-Fortanet, J., Acker, M.G., Antonakos, B., Chen, C.H., Chen, Z., Cooke, V.G., Dobson, J.R., Deng, Z., Fei, F., Firestone, B., Fodor, M., Fridrich, C., Gao, H., Grunenfelder, D., Hao, H.X., Jacob, J., Ho, S., Hsiao, K., Kang, Z.B., Karki, R., Kato, M., Larrow, J., La Bonte, L.R., Lenoir, F., Liu, G., Liu, S., Majumdar, D., Meyer, M.J., Palermo, M., Perez, L., Pu, M., Price, E., Quinn, C., Shakya, S., Shultz, M.D., Slisz, J., Venkatesan, K., Wang, P., Warmuth, M., Williams, S., Yang, G., Yuan, J., Zhang, J.H., Zhu, P., Ramsey, T., Keen, N.J., Sellers, W.R., Stams, T., Fortin, P.D.
Nature