CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00918
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918
CAH2_HUMAN
Homo sapiens
Carbonic anhydrase 2

PDB Structure

PDB 5EH8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination.
Woods, L.A., Dolezal, O., Ren, B., Ryan, J.H., Peat, T.S., Poulsen, S.A.
J.Med.Chem.