CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P0AD64
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P0AD64
BLA1_KLEPN
Klebsiella pneumoniae
Beta-lactamase SHV-1

PDB Structure

PDB 5EE8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030.
Nguyen, N.Q., Krishnan, N.P., Rojas, L.J., Prati, F., Caselli, E., Romagnoli, C., Bonomo, R.A., van den Akker, F.
Antimicrob.Agents Chemother.