CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family mRNA cap guanine-N7 methyltransferase

Enzyme Information

2.1.1.56
mRNA (guanine-N(7)-)-methyltransferase.
based on mapping to UniProt O43148
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
-!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine.

UniProtKB Entries (1)

O43148
MCES_HUMAN
Homo sapiens
MRNA cap guanine-N7 methyltransferase

PDB Structure

PDB 5E9W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.
Varshney, D., Petit, A.P., Bueren-Calabuig, J.A., Jansen, C., Fletcher, D.A., Peggie, M., Weidlich, S., Scullion, P., Pisliakov, A.V., Cowling, V.H.
Nucleic Acids Res.