CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Myosin heavy chain kinase A

Enzyme Information

2.7.11.7
[Myosin heavy-chain] kinase.
based on mapping to UniProt P42527
ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate.
-!- The enzyme from Dictyostelium sp. (slime molds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. -!- One threonine residue in each heavy chain acts as acceptor. -!- While the enzyme from some species is activated by actin, in other cases Ca(2+)/calmodulin are required for activity. -!- Formerly EC 2.7.1.129.

UniProtKB Entries (1)

P42527
MHCKA_DICDI
Dictyostelium discoideum
Myosin heavy chain kinase A

PDB Structure

PDB 5E4H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) alpha-kinase domain apoenzyme reveals a novel autoinhibited conformation.
Ye, Q., Yang, Y., van Staalduinen, L., Crawley, S.W., Liu, L., Brennan, S., Cote, G.P., Jia, Z.
Sci Rep