CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.2600
Functional Family Dipeptidyl peptidase 3

Enzyme Information

3.4.14.4
Dipeptidyl-peptidase III.
based on mapping to UniProt Q9NY33
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
-!- A cytosolic peptidase that is active at neutral pH. -!- It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2. -!- Active in the hydrolysis of enkephalins. -!- Belongs to peptidase family M49.

UniProtKB Entries (1)

Q9NY33
DPP3_HUMAN
Homo sapiens
Dipeptidyl peptidase 3

PDB Structure

PDB 5E3C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.
Kumar, P., Reithofer, V., Reisinger, M., Wallner, S., Pavkov-Keller, T., Macheroux, P., Gruber, K.
Sci Rep