CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt P9WPC4
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

P9WPC2
CLPP2_MYCTO
Mycobacterium tuberculosis CDC1551
ATP-dependent Clp protease proteolytic subunit 2

PDB Structure

PDB 5DZK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.
Li, M., Kandror, O., Akopian, T., Dharkar, P., Wlodawer, A., Maurizi, M.R., Goldberg, A.L.
J.Biol.Chem.