CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.200 | Protein kinase-like fold |
|
3.20.200.10 | MHCK/EF2 kinase |
Domain Context
CATH Clusters
| Superfamily | MHCK/EF2 kinase |
| Functional Family | Eukaryotic elongation factor 2 kinase |
Enzyme Information
| 2.7.11.7 |
[Myosin heavy-chain] kinase.
based on mapping to UniProt P42527
ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate.
-!- The enzyme from Dictyostelium sp. (slime molds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. -!- One threonine residue in each heavy chain acts as acceptor. -!- While the enzyme from some species is activated by actin, in other cases Ca(2+)/calmodulin are required for activity. -!- Formerly EC 2.7.1.129.
|
UniProtKB Entries (1)
| P42527 |
MHCKA_DICDI
Dictyostelium discoideum
Myosin heavy chain kinase A
|
PDB Structure
| PDB | 5DYJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) alpha-kinase domain apoenzyme reveals a novel autoinhibited conformation.
Sci Rep
|