CATH Classification

Domain Context

CATH Clusters

Superfamily lpxc deacetylase, domain 1
Functional Family UDP-3-O-acyl-N-acetylglucosamine deacetylase

Enzyme Information

3.5.1.108
UDP-3-O-acyl-N-acetylglucosamine deacetylase.
based on mapping to UniProt P47205
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- The enzyme catalyzes a committed step in the biosynthesis of lipid A. -!- Formerly EC 3.5.1.n1.

UniProtKB Entries (1)

P47205
LPXC_PSEAE
Pseudomonas aeruginosa PAO1
UDP-3-O-acyl-N-acetylglucosamine deacetylase

PDB Structure

PDB 5DRR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Drug design from the cryptic inhibitor envelope.
Lee, C.J., Liang, X., Wu, Q., Najeeb, J., Zhao, J., Gopalaswamy, R., Titecat, M., Sebbane, F., Lemaitre, N., Toone, E.J., Zhou, P.
Nat Commun