CATH Classification

Domain Context

CATH Clusters

Superfamily lpxc deacetylase, domain 1
Functional Family

Enzyme Information

3.5.1.108
UDP-3-O-acyl-N-acetylglucosamine deacetylase.
based on mapping to UniProt O67648
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- The enzyme catalyzes a committed step in the biosynthesis of lipid A. -!- Formerly EC 3.5.1.n1.

UniProtKB Entries (1)

O67648
LPXC_AQUAE
Aquifex aeolicus VF5
UDP-3-O-acyl-N-acetylglucosamine deacetylase

PDB Structure

PDB 5DRP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Drug design from the cryptic inhibitor envelope.
Lee, C.J., Liang, X., Wu, Q., Najeeb, J., Zhao, J., Gopalaswamy, R., Titecat, M., Sebbane, F., Lemaitre, N., Toone, E.J., Zhou, P.
Nat Commun