CATH Classification

Domain Context

CATH Clusters

Superfamily POLO box domain
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt Q07832
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q8CDI2
FBX43_MOUSE
Mus musculus
F-box only protein 43

PDB Structure

PDB 5DMV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
Jia, J.L., Han, Y.H., Kim, H.C., Ahn, M., Kwon, J.W., Luo, Y., Gunasekaran, P., Lee, S.J., Lee, K.S., Bang, J.K., Kim, N.H., Namgoong, S.
Sci Rep