CATH Domain 5di1A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	TRAF2 and NCK-interacting protein kinase isoform 4

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O95819

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O95819

M4K4_HUMAN

Homo sapiens

Mitogen-activated protein kinase kinase kinase kinase 4

PDB Structure

PDB	5DI1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. Ammirati, M., Bagley, S.W., Bhattacharya, S.K., Buckbinder, L., Carlo, A.A., Conrad, R., Cortes, C., Dow, R.L., Dowling, M.S., El-Kattan, A., Ford, K., Guimaraes, C.R., Hepworth, D., Jiao, W., LaPerle, J., Liu, S., Londregan, A., Loria, P.M., Mathiowetz, A.M., Munchhof, M., Orr, S.T., Petersen, D.N., Price, D.A., Skoura, A., Smith, A.C., Wang, J. Acs Med.Chem.Lett.

Network disruptions