CATH Classification

Domain Context

CATH Clusters

Superfamily Hexapeptide repeat proteins
Functional Family Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Enzyme Information

2.3.1.129
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase.
based on mapping to UniProt A6V1E4
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D- glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)- N-acetyl-alpha-D-glucosamine.
-!- Involved with EC 2.4.1.182 and EC 2.7.1.130 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

UniProtKB Entries (1)

A6V1E4
LPXA_PSEA7
Pseudomonas aeruginosa PA7
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

PDB Structure

PDB 5DEM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of Pseudomonas aeruginosa LpxA Reveal the Basis for Its Substrate Selectivity.
Smith, E.W., Zhang, X., Behzadi, C., Andrews, L.D., Cohen, F., Chen, Y.
Biochemistry