CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-directed RNA polymerase, insert domain
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q5SHR6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q5SKW1
Q5SKW1_THET8
Thermus thermophilus HB8
RNA polymerase sigma factor SigA

PDB Structure

PDB 5D4D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Bird, J.G., Zhang, Y., Tian, Y., Panova, N., Barvik, I., Greene, L., Liu, M., Buckley, B., Krasny, L., Lee, J.K., Kaplan, C.D., Ebright, R.H., Nickels, B.E.
Nature