CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P00533
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29353
SHC1_HUMAN
Homo sapiens
SHC-transforming protein 1

PDB Structure

PDB 5CZI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
Begley, M.J., Yun, C.H., Gewinner, C.A., Asara, J.M., Johnson, J.L., Coyle, A.J., Eck, M.J., Apostolou, I., Cantley, L.C.
Nat.Struct.Mol.Biol.