CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Casein kinase II subunit alpha

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P68400
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P68400
CSK21_HUMAN
Homo sapiens
Casein kinase II subunit alpha

PDB Structure

PDB 5CU2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
De Fusco, C., Brear, P., Iegre, J., Georgiou, K.H., Sore, H.F., Hyvonen, M., Spring, D.R.
Bioorg. Med. Chem.