CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.50
Functional Family

Enzyme Information

3.3.2.8
Limonene-1,2-epoxide hydrolase.
based on mapping to UniProt Q9ZAG3
1,2-epoxymenth-8-ene + H(2)O = menth-8-ene-1,2-diol.
-!- Involved in the monoterpene degradation pathway of the actinomycete Rhodococcus erythropolis. -!- The enzyme hydrolyzes several alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. -!- It differs from the previously described epoxide hydrolases (EC 3.3.2.4, EC 3.3.2.6, EC 3.3.2.7, EC 3.3.2.9 and EC 3.3.2.10) as it is not inhibited by 2-bromo-4'-nitroacetophenone, diethyl pyrocarbonate, 4-fluorochalcone oxide or 1,10-phenanthroline.

UniProtKB Entries (1)

Q9ZAG3
LIMA_RHOER
Rhodococcus erythropolis
Limonene-1,2-epoxide hydrolase

PDB Structure

PDB 5CF1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the M32V/M78V/I80V/L114F mutant of LEH
Wu, L., Sun, Z.T., Reetz, M.T., Zhou, J.H.
To Be Published