CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Enzyme Information

2.1.1.-
Methyltransferases.
based on mapping to UniProt Q96FX7
2.1.1.220
tRNA (adenine(58)-N(1))-methyltransferase.
based on mapping to UniProt Q96FX7
S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
-!- The enzyme specifically methylates adenine(58) in tRNA. -!- The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast. -!- Formerly EC 2.1.1.36.

UniProtKB Entries (1)

Q96FX7
TRM61_HUMAN
Homo sapiens
TRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

PDB Structure

PDB 5CCX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
Finer-Moore, J., Czudnochowski, N., O'Connell, J.D., Wang, A.L., Stroud, R.M.
J.Mol.Biol.