CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Succinate--CoA ligase [ADP-forming] subunit alpha

Enzyme Information

6.2.1.4
Succinate--CoA ligase (GDP-forming).
based on mapping to UniProt O19069
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
-!- Itaconate can act instead of succinate and ITP instead of GTP.
6.2.1.5
Succinate--CoA ligase (ADP-forming).
based on mapping to UniProt O19069
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

UniProtKB Entries (1)

O19069
SUCA_PIG
Sus scrofa
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

PDB Structure

PDB 5CAE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the binding of succinate to succinyl-CoA synthetase.
Huang, J., Fraser, M.E.
Acta Crystallogr D Struct Biol