CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1970 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1970 |
| Functional Family |
Enzyme Information
| 4.1.1.21 |
Phosphoribosylaminoimidazole carboxylase.
based on mapping to UniProt Q73PV9
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1- (5-phospho-D-ribosyl)imidazole + CO(2).
-!- While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18. -!- 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
|
UniProtKB Entries (1)
| Q73PV9 |
PURE_TREDE
Treponema denticola ATCC 35405
Phosphoribosylaminoimidazole carboxylase
|
PDB Structure
| PDB | 5C5D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Function of conserved residues in the class II PurE active site
To be published
|