CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family ABO glycosyltransferase B antigen

Enzyme Information
Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase.
based on mapping to UniProt P16442
UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl- (1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl- (1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.
-!- Acts on blood group substance H. -!- Can use a number of 2-fucosyl-galactosides as acceptors.
Fucosylgalactoside 3-alpha-galactosyltransferase.
based on mapping to UniProt P16442
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.
-!- Acts on blood group substance, and can use a number of 2-fucosyl- galactosides as acceptors.

UniProtKB Entries (1)

Homo sapiens
Histo-blood group ABO system transferase

PDB Structure

PDB 5C36
External Links
Primary Citation
High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise Manner.
Gagnon, S.M., Meloncelli, P.J., Zheng, R.B., Haji-Ghassemi, O., Johal, A.R., Borisova, S.N., Lowary, T.L., Evans, S.V.