CATH Classification

Domain Context

CATH Clusters

Superfamily Ankyrin repeat-containing domain
Functional Family Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.-
Pentosyltransferases.
based on mapping to UniProt Q9H2K2
2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q9H2K2
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q9H2K2
TNKS2_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase tankyrase-2

PDB Structure

PDB 5BXU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human Tankyrase-2 in Complex with Extended Stapled Peptide sp4n4m5
Xu, W., Lau, Y.H., Fischer, G., Chattopadhyay, A., Tan, Y.S., Verma, C., Hyvonen, M., Spring, D.S., Itzhaki, L.S.
to be published