CATH Classification

Domain Context

CATH Clusters

Superfamily Membrane associated eicosanoid/glutathione metabolism-like domain
Functional Family Microsomal glutathione S-transferase 1

Enzyme Information

5.3.99.3
Prostaglandin-E synthase.
based on mapping to UniProt O14684
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

O14684
PTGES_HUMAN
Homo sapiens
Prostaglandin E synthase

PDB Structure

PDB 5BQH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.
Schiffler, M.A., Antonysamy, S., Bhattachar, S.N., Campanale, K.M., Chandrasekhar, S., Condon, B., Desai, P.V., Fisher, M.J., Groshong, C., Harvey, A., Hickey, M.J., Hughes, N.E., Jones, S.A., Kim, E.J., Kuklish, S.L., Luz, J.G., Norman, B.H., Rathmell, R.E., Rizzo, J.R., Seng, T.W., Thibodeaux, S.J., Woods, T.A., York, J.S., Yu, X.P.
J.Med.Chem.