CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family Nucleotide triphosphate diphosphatase NUDT15

Enzyme Information

3.6.1.9
Nucleotide diphosphatase.
based on mapping to UniProt Q9NV35
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.
-!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA. -!- Formerly EC 3.6.1.19.

UniProtKB Entries (1)

Q9NV35
NUD15_HUMAN
Homo sapiens
Nucleotide triphosphate diphosphatase NUDT15

PDB Structure

PDB 5BON
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Carter, M., Jemth, A.S., Hagenkort, A., Page, B.D., Gustafsson, R., Griese, J.J., Gad, H., Valerie, N.C., Desroses, M., Bostrom, J., Warpman Berglund, U., Helleday, T., Stenmark, P.
Nat Commun