CATH Classification

Domain Context

CATH Clusters

Superfamily Zinc/RING finger domain, C3HC4 (zinc finger)
Functional Family Histone deacetylase 6

Enzyme Information

3.5.1.98
Histone deacetylase.
based on mapping to UniProt Q9UBN7
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q9UBN7
HDAC6_HUMAN
Homo sapiens
Histone deacetylase 6

PDB Structure

PDB 5B8D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
Harding, R.J., Ferreira de Freitas, R., Collins, P., Franzoni, I., Ravichandran, M., Ouyang, H., Juarez-Ornelas, K.A., Lautens, M., Schapira, M., von Delft, F., Santhakumar, V., Arrowsmith, C.H.
J. Med. Chem.