CATH Domain 5ayxF01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1170	Aldehyde Oxidoreductase; domain 3
	3.90.1170.20	Quinolinate phosphoribosyl transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Quinolinate phosphoribosyl transferase, N-terminal domain
Functional Family	Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Enzyme Information

2.4.2.19

Nicotinate-nucleotide diphosphorylase (carboxylating).

based on mapping to UniProt Q15274

Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

-!- The reaction is catalyzed in the opposite direction. -!- Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.

UniProtKB Entries (1)

Q15274

NADC_HUMAN

Homo sapiens

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

PDB Structure

PDB	5AYX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis Youn, H.-S., Kim, T.G., Kim, M.-K., Kang, G.B., Kang, J.Y., Lee, J.-G., An, J.Y., Park, K.R., Lee, Y., Im, Y.J., Lee, J.H., Eom, S.H. Sci Rep