CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family

Enzyme Information

3.2.2.27
Uracil-DNA glycosylase.
based on mapping to UniProt P10186
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.

UniProtKB Entries (2)

P10186
UNG_HHV11
Human alphaherpesvirus 1 strain 17
Uracil-DNA glycosylase
Q936H5
Q936H5_STAAU
Staphylococcus aureus
Uncharacterized protein

PDB Structure

PDB 5AYS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase.
Wang, H.C., Ho, C.H., Chou, C.C., Ko, T.P., Huang, M.F., Hsu, K.C., Wang, A.H.
Nucleic Acids Res.