CATH Domain 5ayfA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.20	Single Sheet
	2.20.110	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
	2.20.110.10	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain

Domain Context

CATH Clusters

Superfamily	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
Functional Family	Histone-lysine N-methyltransferase SETD7

Enzyme Information

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q8WTS6

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

SETD7_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase SETD7

PDB Structure

PDB	5AYF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription Takemoto, Y., Ito, A., Niwa, H., Okamura, M., Fujiwara, T., Hirano, T., Handa, N., Umehara, T., Sonoda, T., Ogawa, K., Tariq, M., Nishino, N., Dan, S., Kagechika, H., Yamori, T., Yokoyama, S., Yoshida, M. J.Med.Chem.