CATH Classification

Domain Context

CATH Clusters

Superfamily 6.20.320.10
Functional Family

Enzyme Information

2.4.2.-
Pentosyltransferases.
based on mapping to UniProt Q9H2K2
2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q9H2K2
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q9H2K2
TNKS2_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase tankyrase-2

PDB Structure

PDB 5ADR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors.
Haikarainen, T., Waaler, J., Ignatev, A., Nkizinkiko, Y., Venkannagari, H., Obaji, E., Krauss, S., Lehtio, L.
Bioorg.Med.Chem.Lett.