CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 1
Functional Family Aldehyde dehydrogenase, mitochondrial

Enzyme Information

1.2.1.36
Retinal dehydrogenase.
based on mapping to UniProt P00352
Retinal + NAD(+) + H(2)O = retinoate + NADH.
-!- Acts on both the 11-trans- and 13-cis-forms of retinal.
1.2.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P00352

UniProtKB Entries (1)

P00352
AL1A1_HUMAN
Homo sapiens
Retinal dehydrogenase 1

PDB Structure

PDB 5AC2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues.
Koch, M.F., Harteis, S., Blank, I.D., Pestel, G., Tietze, L.F., Ochsenfeld, C., Schneider, S., Sieber, S.A.
Angew.Chem.Int.Ed.Engl.