CATH Domain 5aavA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.565	Retinoid X Receptor
	1.10.565.10	Retinoid X Receptor

Domain Context

CATH Clusters

Superfamily	Retinoid X Receptor
Functional Family	Estrogen receptor

Enzyme Information

UniProtKB Entries (1)

ESR1_HUMAN

Homo sapiens

Estrogen receptor

PDB Structure

PDB	5AAV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist. De Savi, C., Bradbury, R.H., Rabow, A.A., Norman, R.A., De Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R., Currie, G.S., Davies, C., Donald, C., Feron, L., Hayter, B.R., Hussain, S., Karoutchi, G., Lamont, S., Macfaul, P.A., Moss, T.A., Pearson, S., Tonge, M., Walker, G., Weir, H., Wilson, Z. J.Med.Chem.