CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt E1ANH6
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

E1ANH6
BLC97_ECOLX
Escherichia coli
Beta-lactamase CTX-M-97

PDB Structure

PDB 5A90
External Links
Method NEUTRON DIFFRACTION
Organism
Primary Citation
Exploring the Mechanism of Beta-Lactam Ring Protonation in the Class a Beta-Lactamase Acylation Mechanism Using Neutron and X-Ray Crystallography.
Vandavasi, V.G., Weiss, K.L., Cooper, J.B., Erskine, P.T., Tomanicek, S.J., Ostermann, A., Schrader, T.E., Ginell, S.L., Coates, L.
J.Med.Chem.