CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Carboxylic ester hydrolase

Enzyme Information

3.1.1.56
Methylumbelliferyl-acetate deacetylase.
based on mapping to UniProt P23141
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
-!- Acts on short-chain acyl esters of 4-methylumbelliferone, but not on naphthyl, indoxyl or thiocholine esters.
3.1.1.1
Carboxylesterase.
based on mapping to UniProt P23141
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
-!- Wide specificity; also hydrolyzes vitamin A esters. -!- The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4 and EC 3.5.1.13. -!- Formerly EC 3.1.1.12.

UniProtKB Entries (1)

P23141
EST1_HUMAN
Homo sapiens
Liver carboxylesterase 1

PDB Structure

PDB 5A7F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.
Arena De Souza, V., Scott, D.J., Nettleship, J.E., Rahman, N., Charlton, M.H., Walsh, M.A., Owens, R.J.
Plos One