CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.15 | Metallo-beta-lactamase; Chain A |
|
3.60.15.10 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
| Functional Family | Metallo-beta-lactamase NDM-1 |
Enzyme Information
| 3.5.2.6 |
Beta-lactamase.
based on mapping to UniProt C7C422
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.
|
UniProtKB Entries (1)
| C7C422 |
BLAN1_KLEPN
Klebsiella pneumoniae
Metallo-beta-lactamase type 2
|
PDB Structure
| PDB | 5A5Z |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Approved Drugs Containing Thiols as Inhibitors of Metallo-beta-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.
J. Med. Chem.
|