CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt Q13627
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q13627
DYR1A_HUMAN
Homo sapiens
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB Structure

PDB 5A3X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules
Rothweiler, U., Stensen, W., Brandsdal, B.O., Isaksson, J., Leeson, F.A., Eugh, R.A., Mjoen Svendsen, J.S.
J.Med.Chem.