CATH Domain 5a3nA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.650	Cupin

Domain Context

CATH Clusters

Superfamily	Cupin
Functional Family	Putative lysine-specific demethylase 5b

Enzyme Information

1.14.11.-

With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

based on mapping to UniProt Q9UGL1

UniProtKB Entries (1)

KDM5B_HUMAN

Homo sapiens

Lysine-specific demethylase 5B

PDB Structure

PDB	5A3N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Tumber, A., Nuzzi, A., Hookway, E.S., Hatch, S.B., Velupillai, S., Johansson, C., Kawamura, A., Savitsky, P., Yapp, C., Szykowska, A., Wu, N., Bountra, C., Strain-Damerell, C., Burgess-Brown, N.A., Ruda, G.F., Fedorov, O., Munro, S., England, K.S., Nowak, R.P., Schofield, C.J., La Thangue, N.B., Pawlyn, C., Davies, F., Morgan, G., Athanasou, N., Muller, S., Oppermann, U., Brennan, P.E. Cell Chem Biol