CATH Classification

Domain Context

CATH Clusters

Superfamily 3.60.21.10
Functional Family Serine/threonine-protein phosphatase

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt P53041
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

P53041
PPP5_HUMAN
Homo sapiens
Serine/threonine-protein phosphatase 5

PDB Structure

PDB 4ZVZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Chattopadhyay, D., Swingle, M.R., Salter, E.A., Wood, E., D'Arcy, B., Zivanov, C., Abney, K., Musiyenko, A., Rusin, S.F., Kettenbach, A., Yet, L., Schroeder, C.E., Golden, J.E., Dunham, W.H., Gingras, A.C., Banerjee, S., Forbes, D., Wierzbicki, A., Honkanen, R.E.
Biochem. Pharmacol.