CATH Domain 4ztzC01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.930	BirA Bifunctional Protein; domain 2
	3.30.930.10	Bira Bifunctional Protein; Domain 2

Domain Context

CATH Clusters

Superfamily	Bira Bifunctional Protein; Domain 2
Functional Family	DNA polymerase subunit gamma-2, mitochondrial

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt Q9UHN1

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P54098

DPOG1_HUMAN

Homo sapiens

DNA polymerase subunit gamma-1

PDB Structure

PDB	4ZTZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase Szymanski, M.R., Kuznestov, V.B., Shumate, C.K., Meng, Q., Lee, Y.-S., Patel, G., Patel, S.S., Yin, Y.W. EMBO J.