CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.20.110
Functional Family

Enzyme Information

3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P14350
3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt P14350
2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt P14350
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4
Ribonuclease H.
based on mapping to UniProt P14350
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P14350
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P14350

UniProtKB Entries (1)

P14350
POL_FOAMV
Human spumaretrovirus
Pro-Pol polyprotein

PDB Structure

PDB 4ZTF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Raheem, I.T., Walji, A.M., Klein, D., Sanders, J.M., Powell, D.A., Abeywickrema, P., Barbe, G., Bennet, A., Clas, S.D., Dubost, D., Embrey, M., Grobler, J., Hafey, M.J., Hartingh, T.J., Hazuda, D.J., Miller, M.D., Moore, K.P., Pajkovic, N., Patel, S., Rada, V., Rearden, P., Schreier, J.D., Sisko, J., Steele, T.G., Truchon, J.F., Wai, J., Xu, M., Coleman, P.J.
J.Med.Chem.